Tyrosine supplementation for phenylketonuria treatment
نویسندگان
چکیده
منابع مشابه
Randomised controlled trial of tyrosine supplementation on neuropsychological performance in phenylketonuria.
OBJECTIVE To test the efficacy of tyrosine supplementation, as an adjunct to dietary treatment, on neuropsychological test performance in individuals with phenylketonuria. DESIGN A randomised controlled trial of tyrosine supplementation using a double blind crossover procedure with three four week phases. SETTING The Hospital for Sick Children, Toronto. PARTICIPANTS 21 individuals with ph...
متن کاملTreatment of classical phenylketonuria.
This paper presents some observations on the dietary treatment of phenylketonuric children seen in Glasgow during the past decade. Both the efficacy of the low phenylalanine diet in preventing brain damage (Bessman, 1966), and the adequacy of diagnostic criteria when applied in early infancy (Schneider and Garrard, 1966; Stephenson and McBean, 1967a) have recently been questioned. We therefore ...
متن کاملAdjuvant Treatment for Phenylketonuria (PKU) Executive Summary
Etiology Phenylketonuria (PKU) is a metabolic disorder in which an inability to properly metabolize the amino acid phenylalanine (Phe) leads to a buildup of Phe in the blood, causing neurotoxicity and resulting in intellectual disability, delayed speech, seizures, and behavior abnormalities. Individuals with PKU are also susceptible to other adverse outcomes, including impaired executive functi...
متن کاملThe dietary treatment of phenylketonuria.
Phenylketonuria is an inborn error of the metabolism of phenylalanine associated almost invariably with grave mental deficiency, and often with epilepsy resembling petit mal. It was suggested that the mental deficiency was due to an intoxication by phenylalanine or one of its metabolites and might be relieved by feeding a diet low in phenylalanine (Woolf and Vulliamy, 1951). An economically pra...
متن کاملFuture treatment strategies in phenylketonuria.
Phenylketonuria (PKU) was the first inherited metabolic disease in which treatment was found to prevent clinical features of the disorder; dietary management was established almost 60 years ago. The institution of a low-phenylalanine (Phe) diet in the first few weeks of life was made possible by Guthrie neonatal screening, which further increased effectiveness of therapy. Indeed, neonatal diagn...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 1996
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/64.6.974